The effects of K+ channel blockade on eccentric and isotonic twitch and fatiguing contractions in situ
K+ channel blockers like 3,4-diaminopyridine (DAP) can double isometric muscle force.Functional movements require more complex concentric and eccentric contractions, however the effects of K+ channel blockade on these types of contractions in situ are unknown.Extensor digitorum longus (EDL) muscles were stimulated in situ with and without DAP in an